254 Veterinary Medicine. 



In the high, dry altitudes of the Plains and Rocky Mountains, 

 where most cases of glanders are mild and the majority recover, 

 resort may be had to malleinization provided the patients are 

 kept safely secluded from all other horses. In some horses with 

 a native tendency to immunity, the oft repeated inoculation with 

 0.5 cc. of mallein will render the animal refractory to the infec- 

 tion. Animals that have recovered from casual attacks show the 

 same immunity. Among tho.se who have experimented with 

 mallein may be named : Straus, Schneidemuhl, Semmer, Bonome, 

 and Vivaldi, Mowry and Michel, Schweinitz and Kilborne. 

 Sacharoff apparently secured immunity in the horse by inocula- 

 tion with virus modified by passing through the cat. Straus 

 found that dogs which had received mallein intravenou,sly could 

 be made immune against intravenous inoculations, but, as Galtier 

 had already pointed out, were still susceptible to cutaneous in- 

 oculations. Finger, experimenting on the rabbit, found that im- 

 munity only resulted after a long series of inoculations. The 

 frequency of successful auto-inoculations in chronic cases of 

 glanders in the horse would tend to discredit the alleged value 

 of single injections of mallein, so that a long series is necessary 

 if we would aim at good results. 



Altogether attempts at immunizing the equine population gene- 

 rally, are not hopeful where it is dense, where they must be kept 

 stabled, where the climate is moist and where glanders is deadly, 

 or tends to persist in the chronic form for years in the same ani- 

 mal. 



Considering the prevalence of the disease in a mild form on 

 many of the western breeding ranches it is well to test all horses 

 arriving from the west. The same applies to solipeds imported 

 from abroad. 



TREATMENT OP ANIMAI^. 



In the majority of the states the treatment of a glandered horse 

 is prohibited by .statute. Yet without providing definite machin- 

 ery for the administration of the law, and without idemnities for 

 horses disposed of, such laws are largely inoperative. On the 

 other hand treatment is quite successful on the pastures of our 

 dry table lands and mountains. It can, however, be .sanctioned 

 only when careful .segregation and disinfection are provided for. 



