Rabies and Hydrophobia. Lesions, Treatment, Prevention. 287 



In Pasteur's early experiments he began injecting the emulsion 

 of the cord desiccated for 14 days, following with that of the 13th 

 day, and so on to that of the 5th. It was soon found that this 

 was comparatively ineffective when inoculation had been made 

 with a strong virus or in a large dose, and the treatment for such 

 cases was modified to what is now known as the intensive method. 

 The weaker forms of the virus are given at shorter intervals on 

 the first days of treatment, and the stronger forms repeated again 

 and again, and, in place of a 15 days, course of treatment, this is 

 extended to 21 days. The following table illustrates the course : 



Day of Treatment. 



Number of Days 



that cord had been 



desiccated. 



1st day ■< 



2d 



3d 



4th 



5th 



6th 



7th 



8th 



9th 



loth 



nth ' 



i2th ' 



13th' 



14th ' 



15th' 



1 6th ' 



17th ' 



i8th ' 



19th ' 



20th ' 



2ist ' 



M: 



f 12 " 



.-evemng.|jj ., 

 . morning. \ 

 ..evening, -j 



10 

 9 



. morning, 

 .evening. 



7 

 6 

 6 

 5 

 5 

 4 

 3 

 4 

 3 

 5 

 5 

 4 

 4 

 3 

 3 

 5 

 4 

 3 

 5 

 4 

 3 



Dose Injected. 



3CC. 



}■ 



3CC. 



2CC. 



2CC. 



2CC. 



2CC. 



ICC. 



2CC. 



I>^CC. 



2CC. 



2CC. 



2CC. 



2CC. 



2CC. 



2CC. 



2CC. 



2CC. 



2CC. 



2CC. 



2CC. 



2CC. 



Under this treatment the system becomes educated in the pro- 

 duction of antitoxins, and perhaps also in phago-cyto.sis so that 

 when subjected to the lethal doses of three, four, five and six 

 days preservation, it successfully resists them. The most con- 

 clusive argument in favor of its efficacy is this undeniable fact 

 that the individual escapes death under injected doses which in 

 any unprotected system would prove fatal. 



