352 Veterinary Medicine. 



In confluent or complicated cases the fever of invasion is very 

 high, the sheep dull, prostrate, tender to touch along the back 

 and loins particularly, with hurried, labored, panting, breathing, 

 and mawkish, fevered breath, the weakness increases rapidly, 

 standing even may become difiRcult, the wool is loosened and falls 

 off in patches, the exposed skin is red, shading, it may be, into a 

 violet hue. The head droops, the lips and nostrils swell, saliva 

 drivels abundantly, anorexia is complete, though thirst may be 

 ardent, a yellowish and even reddish, foetid discharge may flow 

 from the nose, respiration is difficult, the eyes are watery and 

 deeply sunken, and the head, limbs, breast and abdomen are ex- 

 tensively infiltrated and oedematous. 



Fever does not subside with the occurrence of eruption, which 

 may appear thickly over the whole body, the woolly parts as well as 

 the bare or hairy. The vesicles, which have often a dark, unhealthy 

 look, tend to become confluent, and instead of proceeding regu- 

 larly to maturity, they may remain hard or indolent papules or 

 nodules or blacken and dry up. The secretion, when it takes 

 place, is liable to be a thick, yellowish, foetid pus. The eruption 

 has much more tendency than with the discrete form to invade 

 mucosae, and not infrequently the serosae are involved, especially 

 those covering the lungs, liver and spleen. In the worst cases 

 death may result from the fever before any eruption has taken 

 place, in other cases the extent of the internal lesions tends to 

 hasten a fatal result. With the amount of care that can be given 

 to a flock, confluent cases are usually fatal. 



In connection with the itching and scratching of the nose, 

 abrasions and complex infections ensue, resulting in extensive 

 ulceration and gangrene implicating the nasal cartilages and 

 bones. The eruption around the pasterns may lead to shedding 

 of the hoofs, and sloughing of the whole digital structures. Sup- 

 purating and gangrenous swellings form subcutaneously and in 

 the lymph glands with fatal results. Blindness is especially 

 liable to happen from the formation of the eruption on the con- 

 junctiva and cornea. Ulcerations and sloughs are common on 

 the internal mucosae, and even on the serosse. In implication of 

 the abdominal organs, a foetid diarrhoea is usually present, and 

 in pregnant ewes abortion is the usual result. 



Lesions. The cutaneous lesions are in their niultilocular struc- 

 ture, the same as in cowpox, but differ materially in size and 



