39 6 Veterinary Medicine. 



does not coagulate milk. On gelatine colonies are formed in four 

 days, and there is no liquefaction. 



History of the Outbreak. The outbreak commenced early in 

 January, without any obvious occasion for the introduction of 

 infection. There had been no chicken disease on the place for 25 

 years, and no chickens had been purchased except from a neigh- 

 boring farm where the stock remained healthy. They had been 

 fed on corn meal, wheat bran, wheat tailings and whole corn, 

 together with scorched wheat from a burned barn. The poultry 

 houses were clean and well aired, and after they had been closed 

 there was no abatement of the disease. The water was from a 

 stagnant pool receiving drainage from the stable, but this was no 

 new condition and January is not the driest month with the foul- 

 est water. The suggestion may be hazarded that the infection 

 may have been introduced by the usual infection bearer, the buz- 

 zard, or by some other wild bird, or mammal. 



Pathogenesis. Among the chickens the most rapid and fatal 

 cases were in pullets, then among the laying hens, while the 

 capons and cockerels were less severely affected, and some sur- 

 vived from three to seven days. 



Those inoculated intravenously as a rule sickened on the second 

 or third day with a temperature of no. 7" F., and were found 

 dead the following morning. 



Some took injections of ,25 to icc. in the pectoral muscles with 

 impunity. 



Chickens that had fasted 24 hours, took each daily for 3 days, 

 a few cubes of bread soaked in a fresh bouillon culture. Death 

 followed in four out of six, in from four to thirteen days from the 

 beginning of the experiment. The birds gradually became list- 

 less, refused to eat, and remained quiet in a corner of the cage, 

 with closed eyes and head drooping until it rested on the ground. 

 Diarrhoea was frequent but not invariably present. 



Chickens fed on the chopped up viscera of rabbits that had died 

 of the disease perished in 3 to 10 days. 



A white duck inoculated intravenously with .5 cc of peptonized 

 beef bouillon culture, took ill on the 8th day, and died on the 

 1 2th. There was loss of coordination and use of the wings, tem- 

 perature 109° F. , and necropsy showed valvular endocarditis con- 

 taining the streptococcus. A second duck sickened on the nth 



