Tuberculosis. 475 



and nineteen weeks. The first had tubercular no^dules in the 

 intestine and mesenteric glands/ 



Frothingham injected into the peritoneum of two calves, three 

 and thirteen weeks old, a culture of tubercle bacilli isolated one 

 year before from the liver of a child. Slight local nodules were 

 produced, some like spontaneous tubercle, others granulation 

 tissue. 



Theobald Smith inoculated sputum into the chest and abdomen 

 of the following : 



1 . A yearling heifer, which was killed two months later and 

 showed on the pleura near the seat of infection a mass of tubercles, 

 one by one and a half inch in diameter, with partly caseated 

 centres ; also a nodule one-eighth of an inch on the right lung, 

 and small tubercles attached to the diaphragm and omentum. 



2. A yearling injected in the same way showed in two months 

 on the diaphragm a mass of tubercles two inches in diameter, and 

 a second mass one inch in diameter on the ribs near the seat of 

 infection. Microscopical examination failed to detect bacilli, but 

 there is no evidence that they were sought by culture or inocula- 

 tion. 



3. A cow injected in the chest and killed after two months 

 showed tubercles of the lungs, pleura, and mediastinal glands, 

 partly caseated and containing bacilli. Vascular fringes hung 

 from the pleura. 



4. A cow receiving a chest injection of sputum culture and 

 killed in two months showed fringes and pendulous masses on 

 the pleura, with small tubercles containing cheesy matter and a 

 few bacilli.^ 



Crookshank injected tubercular sputum into the peritoneum of 

 a calf, which died of streptococcus infection on the forty-second 

 day. It showed extensive tubercular deposits in the seat of 

 injection and an abscess the .size of a walnut. Nodular fleshy 

 neoplasms in hundreds studded the mesentery, omentum, liver, 

 spleen, and diaphragm, and small tubercles disseminated through 

 the lungs and liver contained tubercle bacilli. Three abscesses 

 contained streptococci.* 



' Report of Royal Commission of 1895. 



2 Journal of Experimental Medicine, 1898, vol. iii, p. 482. 



» Transactions of the Pathological Society of London, 1891, p. 332. 



