DOURINE. 



Synonyms. Definition : Contagious disease of breeding solipeds, with 

 special lesions in generative and nervous system, and skin, and caused by a 

 trypanosoma. Susceptible animals : horse, dog, rabbit, rat, mouse, ass. His- 

 tory : in Europe and America. Causes : contagion ; coition ; micro- 

 biology ; trypanosoma equiperdum ; its successive stages : i. granules 

 and refrangent spherules; 2; chromatin bodies with two prolongations; 

 3. fusiform body with nucleus and neucleolus and two flagella ; 4. pyriform 

 bodies with flagella ; 5. fusiform body with nucleus, nucleolus and undulat- 

 ing membrane : in blood, sperm, milk, vaginal mucus, sores ; disappears 

 from blood in intermissions and rapidly after death. Lesions : phlegmons 

 of generative organs, papules, vesicles, mottling, swollen inguinal glands, 

 penis, testicles, caseation or atrophy, thickened lymphatics, nervous les- 

 ions, friable bones, arthritis, liver, spleen, kidneys, lungs, lack of red 

 globules, anaemia, muscular atrophy ; in mare, in dog. Symptoms : Horse: 

 incubation II days, [variable ; preputial, scrotal, sub-abdominal swelling, 

 catarrh of genital mucosa, vesicles, sores, swollen penis, semi-erections; 

 paraphymosis, slight fever, tender loins, frequent micturition, paresis, 

 swollen joints, tendons, emaciation marked anemia, apathy, dementia, 

 nasal ulcers, submaxillary swellings. Mare : vulvar swelling, distortion, 

 leucorrhoea, eruption, spots of depigmentation, erection of clitoris, urine in 

 driblets often, inguinal swellings, sterility or abortion, lameness, trembling, 

 great anaemia and emaciation. Diagnosis : from urticaria : from glanders, 

 generative lesions, no response to mallein, paresis : from chronic paraplegia, 

 by its coition cause, and in horses only ; from vesicular exanthema by grav- 

 ity and nervous phenomena. Prognosis : Mortality 70 per cent, and up- 

 wards. Symptoms in ass slight : in dog severe and fatal ; in rabbits severe. 

 Treatment : prevent copulation, castration, local antiseptics early. Preven- 

 tion : prevent copulation of infected and suspected animals, castrate, import 

 only on certificate and on long quarantine. 



Synonyms. Venereal Disease of Solipeds ; Equine Syphilis ; 

 Maladie du Coit ; Chancrous Epizootic; Breeding Paralysis; 

 Epizootic Paraplegia. 



Definition. A contagious affection of solipeds, transmitted by 

 copulation, and attended by specific lesions in the generative 

 organs and nervous system, such as local venereal swellings, 

 chancrous ulcers and cicatrices, dementia and paralysis. 



Susceptibility. As occurring casually the disease is essentially 

 an equine one, yet the following species are susceptible to ex- 

 perimental inoculation in the order named : dogs, rabbits, rats, 



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