38 THE GROUSE DISEASE chap. 



As regards the shape and motihty of the microbe 

 in the guinea-pig, the same holds good that has 

 been said of the mouse. 



The inoculated guinea-pigs which survive show 

 at the seat of inoculation a firm flat tumour which 

 extends on to the chest. About the end of ten days or 

 so, necrosis and sloughing of the indurated part of the 

 groin sets in, which gradually, leads to complete healing. 



In several instances guinea-pigs which had been 

 inoculated with virulent culture, but had survived; 

 were, at the end of twelve to fourteen days, re-inocu- 

 lated with a virulent culture, but no result followed 

 this second inoculation. 



Rabbits inoculated subcutaneously with culture 

 that proved virulent on mice and on guinea-pigs show 

 only a local result. A thickening about the seat of 

 inoculation, due to caseous purulent infiltration, sets in, 

 but remains circumscribed, and in some cases opens 

 as an abscess, which rapidly heals ; or the tumour 

 becomes firmer and smaller and gradually disappears. 

 Only once have I seen a rabbit die during the second 

 day, but neither cover-glass specimens nor cultivations 

 revealed any microbes either in the blood or in the 

 lung. 



In pigeons and fowls the subcutaneous inoculation 

 is not followed by any, not even a local, positive result, 

 the animals remaining lively and well. 



