74 THE GROUSE DISEASE chap. 



death in one to three days in the great majority 

 of the animals ; they die with the same symptoms 

 and with very similar post-mortem appearances : no 

 oedema at the seat of the inoculation, congestion of 

 both lungs, the spleen slightly enlarged ; the heart's 

 blood and the lungs and the spleen contain the bacilli 

 abundantly. Now I inoculated mice with broth 

 culture (24 hours old) of our oedema bacillus, each 

 animal receiving 2-5 minims ; other mice were in- 

 oculated at the same time and in the sartie doses with 

 broth culture (24 hours old) of the grouse bacillus, 

 and a third lot were inoculated at the same time with 

 a mixture in equal parts of the very same broth 

 cultures of our bacillus of malignant oedema and of 

 the grouse disease. The result was very remarkable. 

 Three such series were made : in each series two mice 

 being used for each experiment. In series one, both 

 mice inoculated with the malignant oedema bacillus 

 were ill and weakly, one died before the second day 

 was half over, the other survived ; the two mice done 

 with the grouse culture both died before the second 

 day was over ; and of the two mice done with the 

 mixture, one died on the sixth day, the other survived. 

 In series two, both the mice done with the malignant 

 oedema bacillus died ; one of the two mice done with 

 the grouse culture died on the second day, the other, 

 though very ill, recovered ; of the two mice done with 



