THE MYELINS : DISTRIBUTION 173 



TABLE A. — Showing the Distribution of Myelin Substances 

 in the Organism 



1. Intracellular Myelin Globules : 



A. Physiologic, or associated with normal regressive processes : 



Cells of suprarenal cortex .... Kaiserling and Orgler. 



Granular cells of corpora lutea . . . Kaiserling and Orgler. 



Cells of thymus gland .... Kaiserling and Orgler. 



Cells of mucous membrane of gall bladder . Aschoff. 



B. Pathologic : 



Aortic endothelium, fatty patches . . Aschoff. 



Atheromatous patches of aorta . . . Mettenheimer. 



Lungs : Alveolar epithelium of newborn . Hochheim. 



Bronchial epithelium .... Schmidt. 



Diseased lung tissue .... Mettenheimer. 



Kidney : Epithelium in fatty degeneration . Albrecht, Lohlein. 



Epithelium after arterial ligation . . Albrecht. 



Crystalline lens, cataract .... Mettenheimer. 



Tumours, cells of many cancers and sarcomas Kaiserling and Orgler. 



C. Autolytic : 



Lung, alveolar epithelium .... Albrecht, Hochheim. 

 Kidney and liver cells .... Many observers. 

 Skeletal and heart muscle .... Dietrich and Hegel. 

 Morning sputum ..... Miiller and Schmidt. 



2. Diffused Myelin : (Impure lecithin ?). 



Myelin gained from various tissues by digestion 

 with alcohol ; brain and nerve tissue, spleen, liver, 

 egg yolk, blood, mesenteric chyle, pus, etc. . Virchow. 



3. Myelin in Seobettons : (Also gained by alcoholic 



extraction.) Virchow. 



Bile. 



Contents of small intestine after fatty meal . . Beneke. 



With what Order of Substance are we dealing ? 



My attention was forcibly directed to this class of substances 

 through certain observations made in my laboratory by Dr. 

 Oskar Klotz. Studying the experimental production of cal- 

 careous degeneration, he noted that if permeable celloidin 

 capsules, containing oleic acid or neutral fats, be placed in the 

 peritoneal cavity of the rabbit, on removal after a few days 

 the contents give a relatively considerable proportion of calcium 

 salts — salts which had not been there previously, which now 

 are presenfrin definite excess over the normal calcium contents 

 of the rabbit's blood and lymph. The only conclusion to be 

 reached was that in the organism under certain conditions 

 calcium salts may become fixed by fatty substances ; in other 



