92 SWINE PLAGUE 



peared on and between the coils of the intestine. Spleen not enlarged. 



The right lung and chest wall covered with a thin grayish exudate. 

 In the cephalic lobe, two small areas of consolidation ; principal lobe 

 hyperemic. The left pleural cavity lined with a quite thick membran- 

 ous exudate, which covered the entire surface of the lung. On the dor- 

 sal surface of the principal lobe a mass of lung tissue 2 cm. in diameter, 

 firm and of a yellowish-gray color. The remaining portion of the prin- 

 cipal lobe hyperemic ; cephalic lobe in a state of collapse. 



Pericardium covered with a thin cellular exudate. 



Higher degrees of resistance. — None of the treated animals 

 which have coine under our observation have succumbed to a 

 mere extension of the lesion produced at the point of inocula- 

 tion as is occasionally observed after inoculation with certain 

 varities of swine-plague bacteria found in nature. There have 

 been noticed, however, certain peculiar localizations resem- 

 bling those produced in the subcutis after inoculation, and in 

 a few cases the local lesion persisted a considerable length of 

 time. It was quite severe in all fatal cases in which the disease 

 was prolonged several weeks after inoculation, although the 

 real cause of death was due in all such cases to localizations on 

 one or more of the serous membranes. The peculiar forms of 

 disease may be grouped as follows : 



(a) Persistence of local lesions. — Rabbit No. 50 received in the 

 abdominal cavity 3.5 cc. of the sterilized suspension of agar cultures in 3 

 doses. It was subsequently inoculated beneath the skin with o.ooi cc. 

 of a bouillon culture of swine-plague bacteria which produced a large 

 local swelling. On February 25, 1892, nearly eight months after its 

 inoculation, it was chloroformed. The only lesion found was in the 

 subcutaneous tissue. At the point of inoculation the skin was sloughed 

 over an area 3 cm. in diameter. The denuded surface was covered with 

 a thick scab. The subcutis beneath the scab and surrounding the ulcer 

 was infiltrated with pus. A stained cover-glass preparation showed 

 swine-plague bacteria. No other lesions were found. 



{b) Sub-peritoneal abscess. — Rabbit No. 16 was injected intraven- 

 ously with 16 cc. of sterilized bouillon cultures of swine-plague bacteria. 

 After some days it was inoculated beneath the skin with o.ooi cc. of a 

 fresh bouillon culture of virulent swine-plague bacteria. The control 

 rabbit died within twenty hours. Rabbit No. 16 showed no ill effect 

 from the inoculation for several months, when it was noticed that it was 

 becoming emaciated. It died June 1 1 , 1892, one year and six days after 

 its inoculation, with a subperitoneal abscess. 



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