MORBID ANATOMY 337 



ably increased in intensity and accompanied here and there by 

 sibilant rales. She coughed violently at times. Six days 

 after she came to the hospital the breathing became more rapid 

 and difficult and the pulse very much accelerated. The animal 

 did not eat, grew weak rapidly and died four days later, or 

 ten days after admission to the hospital. 



§ 252. Morbid anatomy. The anatomical changes 

 given here are restricted to the case of Pearson and Ravenel. 

 The animal was much emaciated. The mucous membrane of 

 the small intestine was catarrhal and showed a small amount 

 of erosion. All the organs were normal except the lungs. 

 The most striking feature on external examination was the 

 extreme amount of emphysema. The lobules were separated 

 from each other by 3 to 5 mm. and even at some distance from 

 the borders one could see through the crevices by transmitted 

 light. On the surface, the sub pleural connective tissue was 

 distended by large blebs. Upon palpation the lung crackled 

 and numerous hard nodules could be felt. On section numer- 

 ous dark red nodules appeared in the surrounding normal 

 tissue. In each lung there were from fifty to sixty of these 

 nodules, from 5 to 12 mm. in diameter. Most of them were 

 dark red and closely resembled partially organized blood clots. 

 However, on crushing a portion in glycerin between two slides, 

 and examining it under the microscope, they were found to be 

 made up almost entirely of a felted network of mycelial threads. 

 Between these large nodules there were numberless smaller 

 areas of much the same color, i to 2 mm. in diameter, notper-^ 

 ceptible to the touch as nodules but which were of the same 

 character and were no doubt foci of recent origin. These were 

 seen especially well in portions of the lung which were pre- 

 served by Pick's method, the slight bleaching of the tissue 

 bringing them into relief. On opening some of the inter- 

 lobular emphysematous spaces, small, whitish, mouldy look- 

 ing patches were noticed which bordered the cavity. Scrap- 

 ings of these patches were made up entirely of perfect fruit 

 hyphae, with myriads of spores. The diagnosis of a mould 

 mycosis was in this way made at once and confirmed by cul- 



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