MORBID ANATOMY 335 



infiltration made up of round cells, leucocytes, proliferated con- 

 nective tissue cells and red blood corpuscles. The adjacent 

 structures were closely filled with a cellular infiltration with a 

 quantity of mycelium of the same description, this extended 

 to the neighboring alveoli, which under low power appeared 

 to have preserved their outline but with greater amplification 

 were seen to have lost all their normal structure, showing 

 clumps of homogeneous, irregular masses which stained faintly 

 with eosin and were probably of connective tissue origin. 



In these areas the mycelium followed the alveolar wall as 

 a trellis, the tissue seeming to afford no obstacle to its advance. 

 Within the alveoli was a finely granular debris, with some 

 coarser particles, probably the remains of cells. In sections 

 stained with carbol-thionine large numbers of mast cells were 

 seen in the alveolar walls. Bordering these degenerated areas 

 were alveoli which had retained their normal structure and 

 were filled with a network of fibrin holding in its meshes a few 

 cells. In other parts of the sections were areas resembling 

 those just described, but in which all anatomical landmarks 

 had been destroyed, so that it was impossible to tell whether 

 or not the spaces seen were bronchi . 



Some sections showed a widespread interstitial and alveolar 

 hemorrhage, the blood showing a considerable increase in the 

 number of leucocytes. The capillaries were congested and 

 areas of edema with thickening of the alveolar walls were not 

 uncommon. 



There were peribronchitis and arteritis, while in some sec- 

 tions arterial thrombosis was seen, the thrombus being pene- 

 trated by mycelium, though no fruit was found. Areas were 

 also found in which the alveoli were filled with a cellular exu- 

 date producing consolidation and thickening of the alveolar 

 walls. 



Emphysema, both interstitial and vesicular, were marked 

 and often extreme. Around the borders of the interstitial 

 cavities was a distinct zone made up of red blood cells, leuco- 

 cytes and homogeneous material, which was yellowish in fresh 

 as well as stained sections. These areas contained very little 



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