340 



PNBUMONOMYCOSIS 



mycelium. All sections showed a small amount of anthracosis. 

 The appearance of sections varied in different nodules as they 

 were taken further and further away from the center. In 

 general the fungus was thickest at the center, so thick in 

 many instances that the lung tissue was hidden entirely, 

 and grew less as we went outward. The tissue changes noted 

 took place in a zone beyond the greatest growth of the fungus. 

 In other nodules the fungus was evenly distributed throughout, 

 following the alveolar walls. In these the tissue changes were 

 slight. At times the fungus grew in dense, brush-like clusters, 

 closely resembling actinomycosis under low amplification. 



This form was 

 considered to show 

 a marked reaction 

 and resistance on the 

 part of the animal 

 and a lowered vital- 

 ity in the fungus. 

 When found it indi- 

 cated that the asper- 

 gillosis was a pri- 

 mary and not a sec- 

 ondary or terminal 

 affection. No giant 

 cells were found in 

 any section. 



Fruit formation 

 was not observed in 

 the substance of the 

 tissues at any time. 

 It was observed most 

 frequently in bronchi, which were for the most part denuded 

 of their epithelium, and next in emphysematous cavities, 

 where it could be detected in clusters by the naked eye. Fruit 

 was found in sections, in spaces the nature of which it was 

 impossible to determine accurately. Whenever the formation 

 of fruit was seen, there were innumerable free spores as well 



Fig 88. Necrosis in the kidney of a rabbit 

 due to A. fumigatus ; K, fungus ; B and C, 

 nuclei; D, necrotic tissue ; E, normal cells. 



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