MORBID ANATOMY 



363 



As evidence of the diminution of the number of corpuscles 

 within the body these authors point ( i ) to the loss of hemo- 

 globin through the kidneys, (2) to the overproduction of bile 

 which is abnormal in the abundance of pigment and (3) to the 

 actual observation of their destruction by the micro-parasite 

 under the microscope. 



The regeneration of blood corpuscles is indicated perhaps 

 by the count, but more surely by the forms of the corpuscles 

 themselves. The abnormal forms are the very large corpus- 

 cles, "punctate" forms and lastly the diffuse stained or 

 "tinted" forms and the erythroblasts. The first of these 

 may appear when the blood count reaches 3,000,000 and the 

 other forms when it is still lower. These various forms, how- 

 ever, are probably emtryonic or immature corpuscles, which 

 are forced prematurely into the circulation by the blood pro- 

 ducing organs in trying to overcome the rapid destruction of 

 corpuscles by the parasite. The action of the disease upon 

 the leucocytes or the defensive activities of the white corpus- 

 cles in combating the parasite of Texas fever have not been 

 determined. In the work thus far performed and reported, 

 they have received little attention. Suffice it to say that they 

 have not been in evidence in this conflict and probably take 

 little or no part in the morbid changes of Texas fever. 



§ 271. Differential diagnosis. Texas fever is easily 



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