SYMPTOMS 417 



mare nor get an erection. Some patients exhibit permanent 

 tremblings over the whole body or local paralysis as for in- 

 stance, that of the lips, ears and eyelids. Hyperesthesia of the 

 skin is observed particularly in stallions and with it is exten- 

 sive pruritis, so that the animal continually rubs itself, bites 

 the affected parts and thus produces extensive sores on the 

 skin. The patient becomes extremely emaciated especially in 

 the hind quarters so that the outlines of the pelvic bones and 

 ribs become very prominent. The skin becomes dry, the hair 

 is ruffled and loses its gloss. Some animals manifest pain when 

 the lumbar region is pressed. The senses become more and 

 more blunted and the eyes assume a staring and expressionless 

 appearance. As the end approaches the patient persistently 

 maintains a recumbent position and finally dies from the effect 

 of secondary lesions such as hypostatic inflammation of the 

 lurrgs, septicemia or perhaps general cachexia. Sometimes in 

 the final stage the patient suffers from nasal catarrh with 

 swelling of the submaxillary glands and conjunctivitis. Severe 

 internal inflammation of the eyes has been observed. The 

 appetite continues longer than any of the other normal 

 functions. 



Baldrey has divided the symptoms into three different 

 stages, as suggested by Nocard. These stages are distinct, 

 and may, if the case is carefully watched, be recognized com- 

 paratively easily. They are : — 



Primary. In which occur the local manifestations of dis- 

 charge and urethral irritation, and ulceration of the penis and 

 sheath. 



Secondary. In which the exanthematous eruptions appear 

 in the skin — the so-called " plaques ". 



Tertiary. Characterized by the formation of lesions in 

 the central nervous system, and by nervous disturbance with 

 ultimate paraplegia. 



It was probably on account of these three periods that the 

 older writers coufounded the disease with syphilis, and it is 

 also possible that the ulcerations and chronic enlargements of 



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