542 INFECTIVE SARCOMATA 



5. Spinola. Handbuch der. spec. Path. «. Thera. fur. Thie 

 rarzte, 1858. 



6. Ward. Poultry diseases in California. Proceedings of the 

 Am. Vet. Med. Asso , 1904, p. 164. 



INFECTIVE SARCOMATA IN DOGS. 



§ 432. Infective sarcomata in dogs. Smith and Wash- 

 burn have described a series of tumors of dogs which spread 

 from animal to animal as the result of coitus. These tumors 

 which varied much in size appeared to start in the mucosa of 

 the vagina. In some cases the walls of the vagina were 

 deeply infiltrated, and the tumors often ulcerated. Death 

 occurred frequently from cachexia or as the results of mechani- 

 cal obstruction. They were enabled to successfully inoculate 

 the tumors into two dogs. The following are their conclusions: 



1. "The tumors in question are infective round-celled 

 sarcomata occurring in dogs. 



2. "The tumors can be transplanted from the genitals, 

 where they naturally occur, to the subcutaneous tissue of dogs. 



3. "The tumors can be transplanted from subcutaneous 

 tissue to subcutaneous tissue through a series of dogs. 



4. ' 'The tumors after reaching the maximum of growth 

 may disappear spontaneously with or without ulceration. 



5. "The tumors may continue to increase, and may 

 cause death by secondary deposits forming in the viscera. 



6. If the tumor should disappear the animal is then 

 immune to subsequent inoculation." 



Beebe and Ewing have studied these nodular tumors. 

 They have been able to transplant it. From 122 plants by 

 various methods they have produced tumors in 35 cases and 

 there were 12 spontaneous recoveries. The course of the 

 successful implantations is usually quite uniform. When 

 inserted beneath the skin a period of 2 to 3 weeks elapsed 

 before enlargement was noticed. Thereafter the nodules grew 

 steadily in size for four or five months producing a well- 



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