290 MANUAL OF BACTEEIOLOGY. 



In 25 cases of acute cystitis in women Brown* found B. coli 

 communis, 15 times; S. pyogenes albus, 5 times; S. pyogenes 

 aureus, twice; B. typhosus, once; B. pyocyaneus, once; B. 

 proteus vulgaris, once. 



A number of investigators have recovered organisms re- 

 sembling the pyogenic cocci from cases of acute articular 

 -rheumatism. Most frequently a diplococcus or short strepto- 

 coccus has been found, which has sometimes produced ar- 

 thritis and endocarditis when inoculated into rabbits. But 

 Cole'sf investigations seem rather unfavorable to the view 

 that this is the specific organism for acute articular rheumatism. 

 On the other hand Beattie J comes to the conclusion that the 

 organism is specific for the disease, and that M. rheumaticus, 

 is not an attenuated streptococcus. 



From a point where there is suppuration or other localized 

 infection, pyogenic bacteria may enter the circulation and be- 

 come widely disseminated throughout the body. That hap- 

 pens very commonly in malignant endocarditis. In this man- 

 ner secondary or metastatic abscesses may be produced in the 

 most diverse organs. 



In making a diagnosis in such cases, Rotch and Low§ recom- 

 mend taking not less than 5 c.c. of blood. A large antitoxin 

 syringe serves the purpose. This is inserted into the most 

 prominent vein at the elbow joint, after scrubbing with soap 

 and water, and washing with ether and alcohol, and a corrosive 

 sublimate pad tied above. Negative results they believe to 

 be of value in prognosis. They believe the method offers 

 valuable means of diagnosis in obscure conditions, cryptogenic 

 septicemia and autointoxication. 



* Johns Hopkins Hospital Reports. Vol. X. 1902. 



t Cole. Experimental Streptococcus Arthritis in Relation to the Etiology of 

 Acute Articular Rheumatism. Journal of Infectious Diseases. Vol.1. 'Ho a 

 Nov. 5, 1904. P. 714. 



XJourn. Exper. Med. Vol. IX., 1907. pp. 186-206. 



^Journ. Am. Med. Assn. Vol. XL VIII., No. 3. Jan. 19, 1907. pp. 186-189. 



