Pathogenesis. 17 



2. Young pig.— lOc.c. of the virulent blood was 

 injected into a young pig. It died suddenly from a 

 febrile attack after five days. 



3. Half -grown pig.— 10 c.c. of the virulent blood 

 was injected into a half-grown pig. It did not become 

 affected. Consequently one month later 20 c.c. of the 

 blood of the pig was injected into a healthy horse (Ex- 

 perimental horse No. 53). It became affected after a 

 latent period of 27 days. From this experiment it may 

 be concluded that not only is the virus retained for a 

 month in the pig, but also that it increased in amount 

 while in the pig. 



Donkey. 



10. c.c. of the virulent citrated plasma was given 

 subcutaneously to a donkey. The first febrile attack came 

 24 days afterwards, thermometer reading being 39.7°C 

 in the maximum. After four days the temperature be- 

 came normal. The second attack came after 21 days, 

 the temperature staying at 40°-40.5°C. for five days, 

 when the patient died. It lost 11.25 kilograms during the 

 malady {vide accompanying table). 



Goat. 



Young goat.— 5.0 c.c. of a patient's blood was injected 

 into a young goat. Temperature rose after three weeks. 

 Febrile condition lasted for five days, the maximun tem- 

 perature being 40.5°C. After that the temperature re- 

 turned to normal. 



50 c.c. of the blood of an affected horse was injected 

 into a goat. It did not show any sign of illness at all. 

 100 c.c. of the blood was drawn after 38 days from the 

 goat and was injected into a healthy horse (Experi- 



