Pathologic Anatomy and Histology. 33 



B, Histologic Changes. 



The histologic changes of various tissues and organs 

 correspond to the anatomical findings, e.g., anemia, ex- 

 travasation, hypertrophy and degeneration of parenchy- 

 matous organs and the presence of haemoglobin crystals 

 (seen also in fresh material) due to haemolysis. Espe- 

 cially noteworthy is the infiltration of small round cells 

 in parenchymatous organs. 



The lymph-glands and bone-marrow are always more 

 or less swollen. The dark red part of the bone-marrow 

 is rich- in blood and poor in adipose cells, generally 

 infiltrated by round cells. Often many eosinophile louco- 

 cytes and megalocytes are found in it. Sometimes hae- 

 morrhage takes place in the capillaries. 



In the spleen are found haemorrhage, acute splenic 

 tumor, haemoglobin crystals. Often one sees prolifera- 

 tion of the large mononuclear cells and marked increase 

 of haemosiderin granules. In the chronic cases its matrix 

 is always more or less enlarged. 



In the liver one often meets with cloudy swelling, 

 fat infiltration, atrophy of the liver cells, dilatation of 

 capillaries, and infiltration of blood-pigment (especially 

 haemosiderin). Marked is the infiltration of round cells 

 in the interstitial substance and in the lobules. Fat 

 infiltration does not take place in the margin of the 

 lobules as is usually the case, but in the liver cells near 

 the central vein {vide the colored plate at the end of 

 the report). 



In the kidneys are sometimes found haemorrhage, 

 infiltration of round cells, cloudy swelling, and slight fat 

 infiltration. In one instance the suprarenal body totally 

 lacked chromatic substance. 



