34 Symptomatology. 



The heart muscle fibres are always cloudy and in 

 some cases various stages of fatty degeneration have al- 

 ready set in. 



In the mucosa of the stomach and intestine hae- 

 morrhage and slight cell infiltration are sometimes seen. 



Very seldom small haemorrhagic spots are present 

 in the central nervous system. 



In conclusion we may mention that the main histo- 

 logic changes of the disease consist in the disintegration 

 of the red blood corpuscles resulting in haemosiderosis. 

 It is not certain whether these chages in the circulatory 

 system and general nutrition, — e.^f. haemorrhages and 

 fatty infiltration of various tissues and organs,— is due 

 to anemia or direct action of the virus. In any event 

 the disease resembles leucaemia in various symptoms, viz. 

 the presence of elements like round cells in the liver, 

 kindneys, mucosa of the alimentary canal, etc., and the 

 proliferation of the pulp-cells in the spleen. These pa- 

 thologic changes seem to be of the same nature as the 

 hypertrophy of the bone-marrow and the lymph-glands. 



VI. SYMPTOMATOLOGY. 



General Symptoms.— The prominent features of the 

 disease are irregular recurrences of fevers and progres- 

 sive anemia. At first the febrile attack comes suddenly 

 and it subsides almost completely in a short time. This 

 being repeated for several times the patient usually falls 

 into anemia and emaciation. During the progress of 

 the disease, such symptoms as paleness of visible mucous 

 membrane, oedema at various parts of the body, septi- 

 caemic phases and exhaustion appear. Of these, the 



