40 COTJRSE AND PROGNOSIS. 



phile cells are found in addition to the lymph-cells of 

 various sizes. Besides these a small number of the mast- 

 cells and a great many large mononuclear cells are present. 

 Blood-platelets and haemokonia. — During febrile 

 attacks, one notices a considerable increase of blood 

 platelets. Their shape and modes of aggregation are 

 very variable. Besides these, minute spherical or ellipti- 

 cal granules are present. They are identical with the 

 haemokonia found in horses suffering from other febrile 

 diseases. 



VII. COURSE AND PROGNOSIS. 



The disease can conveniently be divided into the 

 acute, the subacute, and the chronic, but no sharp line 

 of demarkation can be drawn between them. In the 

 acute form, high temperature remains for some time. 

 After from a few days to two weeks from the beginning 

 of the disease, the final termination comes always by 

 the appearance of symptoms of septicaemia. 



Those animals, which pass through the first febrile 

 attack, may become better for a time, but a very small 

 proportion of the patients completely recover. In many 

 cases, another febrile exacerbation returns after two or 

 three weeks being accompanied by worse symptoms than 

 the first. They then change into acute cases and some- 

 times may remain for nearly a month. In chronic 

 cases, the disease continues from a few months to over 

 a year, during which time the condition of the disease 

 fluctutates with the recurrence of febrile attacks, or it 

 changes into an acute type, and the final issue comes 

 from anemia and emaciation. 



Prognosis of the disease is generally doubtful, and 



