TUBERCULOSIS 187 
The skin lesions consist of a cellular infiltration usually abont 
the root of the feathers. Frequently the nodules become confluent. 
They may or may not involve the subcutaneous connective tissue. 
The microscopic examination of the tubercles of the liver shows 
them to consist of a necrotic center surrounded by an irregular zone 
of epithelioid and giant cells. This is surrounded by a band of tissue 
consisting for the greater part of liver cells, more or less disintegrated 
free nuclei and a few infiltrated round cells. This zone is circum- 
scribed by a narrow reactionary band consisting very largely of round 
cells. The structure is constant in both small and large tubercles, 
and not strikingly different from the structure of tubercles in certain 
of the mammals. The larger nodules seem in some instances to be 
the result of a continuous growth of a single tubercle, and in others to 
have resulted from the coalescence of a number of smal! ones. The 
necrotic center and reactionary zone of round cells are beautifully 
demonstrated by their reaction to nuclear stains. 
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