NECROBACILLOSIS Q207 
The metabolic products are exceedingly poisonous. At the point of 
entrance the organisms multiply, producing a marked reaction of 
congestion, followed by an exudation rich in fibrin-forming substances 
and a defensive immigration of leucocytes. ‘The products of the 
organism acting upon these defensive processes of the body cause their 
necrosis. With the death of the tissues the bacilli invade the deeper 
Fic. 50, AREAS OF NECROSIS IN THE LIVER OF A PIG DUE TO B. necrophorus. 
layers. The lesions due to this organism are liable to be found, as 
already stated, in any organ of the body or on any mucous membrane 
or the’skin. 
Necrobacillosis of the skin. Necrotic inflammation of the skin or 
dermatitis gangrenosa forms a group of destructive inflammations of 
the skin following various causes such as burning, freezing, slight 
trauma or pressure during which B. necrophorus may gain entrance 
to the tissues. Fréhner describes an enzootic of this disease in horses. 
