292 EPIZOOTIC LYMPHANGITIS 
isolated but later they become confluent. Nodules are occasionally 
found in the liver and spleen. A few horses appear to recover 
spontaneously. A few are apparently benefited by proper treat- 
ment. It is said to be fatal in from 10 to 15 per cent of all cases. 
Diagnosis. This affection is to be diagnosed by the symptoms, 
lesions and by finding the specific organism in the discharges from 
the lesions. 
In 1910, Bridré and Négre demonstrated that the complement 
fixation test could be used to prove that epizodtic lymphangitis 
is due to a blastomyces and not to protozoa. The serum of horses 
suffering from epizodtic lymphangitis gave positive fixation with the 
Cryptococcus farciminosus, or yeasts in general—but not with bacteria 
or Leishmania infantum parasites, etc. A yeast immune serum 
gave fixation with the organisms of lymphangitis, but not with 
bacteria or protozoa. Meyer confirmed their findings. He states 
that the sera from sporotrichotic infections give complement fixation 
with the Cryptococcus farciminosus, indicating a relation of the Sporo- 
thrix Schencki-Beurmanni to the cryptococcus. This observation 
is further proof of the vegetable nature of the parasite of “epizodtic 
lymphangitis.” 
It is to be differentiated from sporotrichosis, glanders, ulcerative 
lymphangitis, tubercular lymphangitis, bursatti, and the so-called 
botryomycosis. The finding of the specific organism in case of 
epizodtic lymphangitis affords a positive means for its diagnosis. 
REFERENCES 
1. Ductavux. Sur un protozoaire dans la lymphangite epizootique du mulet en 
Tunisie. Compt. rend. Soc. de biol., Vol. LXIV (1908), p. 593. 
2. Mertam. The staining of the organism of epizodtic lymphangitis. The Vet. 
Record, Vol. XVI (1904), p. 834. : 
8. Meyer. Epizodtic lymphangitis and sporotrichosis. Am. Journ. of Trop. 
Dis. and Preven. Med., Vol. III (1915), p. 144. 
4. Meyer. The relation of animal to human sporotrichosis. Journ. of the Am. 
Med. Asso., Vol. LXV. (1915), p. 579. 
5. Mouuer. Mycotic lymphangitis of horses. U. 8. Dept. of Agr. B. A. L., 
Circular 1565.’ 
6. Pacz, Frorurncuam anp Paice. Sporothrix and epizodtic lymphangitis. 
Jour. Med. Research, Vol. XXIII (1910), p. 137. 
7. Pawn. A treatise on epizodtic lymphangitis. London, 1904. 
8. Pxarson. Epizodtic lymphangitis of horses and mules. Circular No. 8, 
Pennsylvania State Livestock Sanitary Board, 1907. 
9. Sanrerice. Uber die pathogene Wirkung der Blastomyceten. Zeitsch. f. 
Hyg. u. Infek., Bd. LIV (1906), S. 299. 
10. Toxisuicz. Uber pathogene blastomyceten. Centralbl. f. Bakteriol., Bd. 
XIX (1896), S. 105. 
