298 LEECHES 
the mycelium and also closely applied to the filaments. These 
bodies are not spherical, but thin and flattened, and some of them 
present a curved appearance, convex on the outer side and concave 
on the inner side. They suggest the possibility of having been closely 
applied to the filaments and have something of a scale-like arrange- 
ment. With possibly one exception, no trace of blood vessels has 
been found in the nodules. 
There is an infiltration of the connective tissue with a great number 
of wandering cells. In some places there are well-defined nests in 
the stroma of the connective tissue, simulating, perhaps, a cancerous 
appearance. The character of the cells, which present a curiously 
vacuolated condition, would, however, tend to eliminate this view. 
The vacuoles vary in number and size, the average number being 
1 to 12 in a cell. 
In some preparations numerous leucocytes, of the mononuclear 
and polynuclear varieties, had drifted away from the nodule. They 
were for the most part elongated, and in all the nucleus or nuclei 
appeared to be in a healthy condition. The cells contained numerous 
eosinophiles, which took a deep orange color with the Biondi-Ehrlich 
stain. In places adjacent to these leucocytes there were frequently 
noticed a number of these small bodies apparently lying free in the 
tissue. 
The vacuolated cells are present in greater numbers than the 
heavily laden leucocytes. In the former nuclei are present and present 
various phases of change. In some there is a single nucleus, which 
may be circular, crescentic, or in the form of a dumb-bell; in others 
there may be two or more nuclei which in advanced cases appear only 
asremnants. In extreme cases no nuclei at all are visible. The wall 
of the wandering cell differs from that of the leucocytes proper in 
possessing an appreciable thickness. This thickened boundary 
apparently gives considerable rigidity to the cells, as nearly all of 
them are approximately circular inform. Their average diameter is 
about eight microns. In one specimen there appeared to be large 
giant cells, measuring from 12 to 18 microns and apparently possessing 
quite a distinct cell wall. Within each giant cell there is some appear- 
ance of vacuolated cells, each with a single nucleus and fairly well- 
defined cell boundary. As many as eight or ten of these nuclei have 
been counted in a single giant cell. There is the possibility that these 
apparent giant cells are simply some of the vacuolated cells fused 
together, but the nuclei are well defined and take the stain very 
