INFECTIOUS ENTERO-HEPATITIS 317 
out the liver cells, leaving the connective tissue stroma of the lobules 
in whose meshes they are found. 
Their presence within giant cells is seen in almost every infected 
organ. This intracellular condition is, however, a purely passive one 
so far as the parasite is concerned. 
The microparasites within the tissue of the host seem to tend 
toward destruction. Both the death of the tissue itself and the 
repair seem to lead to the disappearance of the parasites. In most 
cases there may be seen in the same section a partial dissolution of 
some of the bodies, while others are still in good preservation. Evi- 
dently their life within the tissues is not very long. 
A discharge of the microparasites which escape destruction proba- 
bly takes place from the walls of the ceca, when these break down into 
the contents with which they are carried outward. A similar dis- 
charge may take place from the liver through the bile ducts into the 
intestine. Another way of dissemination is in the death of the 
diseased turkey and the dissolution of its body, whereby the organisms 
are set free. 
The occurrence of amebe in intestinal affections of man was noticed 
by Lésch in 1875. Since that time it has been the subject of many 
investigations. 
The points of analogy between the avian and the human disease 
are that in both there is an affection of the intestine (large intestine 
in man, ceca in turkeys) associated with liver disease due to amebe. 
The intestinal wall in amebic dysentery (human) is greatly thick- 
ened, owing to an edematous condition. It is also thickened in cir- 
cumscribed areas and contains cavities filled with gelatinous-looking 
pus. The amebz vary much in size and contain vacuoles. They are 
found in variable numbers in the bottom of the ulcers and in the 
discharges. The large numbers of amebz found in the intestinal 
contents led Councilman and Lafleur to infer an active multiplication 
therein. The presence of the parasites within the submucosa is 
described by these authors in one case only. 
In the turkey, the parasites are always present in the connective 
tissue spaces of the mucous and submucous membrane. Their 
presence in the contents of the cecum is highly probable. 
It differs from the Ameba dysenterie in being quite uniform in 
appearance, varying but slightly in size (from 6 to 10. in diameter) 
and in being free from vacuoles. Movements characterized as ame- 
boid have not yet been demonstrated. 
