366 DOURINE 
swollen, sometimes thickened by gelatinous elevations and covered 
with a turbid and orange colored secretion. The local manifestations 
are sometimes insignificant. The mucous membrane in the neighbor- 
hood of the clitoris is more congested than at other points and the cli- 
toris itself may be swollen and erect. It is devoid of pigment and 
unnaturally dry. Williams states that this depigmentation is 
“peculiar and characteristic.”” The spots of discoloration are not 
caused by previous ulcers. There is excessive sexual excitement. 
Frequently mares suffer from strangury and, after considerable strain- 
ing, urine is discharged in small jets. In his report on the Illinois out- 
break, Williams states that in mares, “The open vulva and enlarged, 
protruding, unnaturally dry clitoris, especially in young and otherwise 
healthy mares is quite pathognomonic.” 
Instead of urine there may be discharged small quantities of sticky, 
discolored mucus. The mucous follicles are swollen and appear as 
nodules. These may develop into small ulcers with sharp borders 
and yellowish bases. There may be vesicles on the vagina and vulva 
which leave ulcers. These usually heal leaving whitish spots. The 
animals shake their tails and open and close the vagina in rapid suc- 
cession, showing the clitoris as mares do in cestrum. The discharge 
often exerts a corrosive action on the tail and legs. In severe cases 
the neighboring lymph glands become inflamed and swollen as well 
as the udder, in which abscesses may appear. The swelling may even 
extend to the hypogastrium. There are many cases in which the 
early symptoms are slight and easily overlooked but the later ones 
are pronounced. 
The general symptoms follow the local ones or develop after weeks 
or even months; their appearance is often delayed until the local 
symptoms have entirely disappeared. At first the animals are de- 
pressed and weak, they frequently continue to lift up their hind feet, 
alternately, so as to try to avoid putting weight upon them, knuckle 
on their fetlock joints and lose control over the movements of their 
hind Jegs while walking. The temperature is not so high as in other 
forms of trypanosma infection. 
The second group of symptoms suggests affection in part of the 
skin, peripheral nerves and intervertebral ganglia. The animals 
suffer from an urticaria in the form of sharply defined, round, flat 
eminences which may be raised the breadth of a finger above the 
surface and which may vary in size from two to four centimeters or 
more in diameter. These have been referred to as ‘dollar spots.” 
