DOURINE 367 
‘They are caused by a serous infiltration of the papillary layer of the 
skin in the neighborhood of a small artery and are evidently of a baso- 
neurotic character. They often appear and disappear very rapidly 
and may shift their position. Usually they persist for several days 
during which time they become moderately hard and then slowly 
disappear. Their favorite sites are the croup, neck, shoulders, chest 
and abdomen. 
Later in the course of the disease, a progressive paralysis of the 
hind quarters combines with excessive emaciation. The paralysis 
may last to the end, or apparent improvement for a time may occur. 
‘The animal has a staggering gait and often gives way on the pasterns 
and at the knees, can raise itself from the gound only with difficulty, 
and sometimes falls down unexpectedly. Some animals exhibit 
permanent tremblings over the whole body or local paralysis as for 
instance, of the lips, ears and eyelids. Hyperesthesia of the skin 
is observed particularly in stallions and with it is extensive pruritis, 
so that the animal continually rubs itself, bites the affected parts and 
thus produces extensive sores on the skin. The patient becomes 
extremely emaciated especially in the hind quarters so that the out- 
lines of the pelvic bones and ribs become prominent. The skin 
becomes dry, the hair is ruffled and loses its gloss. Some animals 
manifest pain when the lumbar region is pressed. The senses become 
more and more blunted and the eyes assume a staring and expression- 
less appearance. As the end approaches the patient persistently 
maintains a recumbent position and finally dies from the effect of 
secondary lesions such as hypostatic inflammation of the lungs, 
septicemia or perhaps general cachexia. There is often a continued 
fever at the end, due to secondary infection. Sometimes in the final 
stage the patient suffers from nasal catarrh with swelling of the sub- 
maxillary glands and conjunctivitis. Severe internal inflammation 
.of the eyes has been observed. The appetite continues longer than 
any of the other normal functions. 
Baldrey has divided the symptoms into three different stages, as 
‘suggested by Nocard. These stages are morc or less distinct, and 
may, if the case is carefully watched, be easily recognized. ‘They are: 
Primary. In which occur the local manifestations of discharge and 
urethral irritation, and ulceration of the penis and sheath. 
Secondary. In which the exanthematous eruptions appear in the 
skin—the so-called ‘“‘plaques.” 
