CANINE DISTEMPER 473 
“The tumors can be transplanted from subcutaneous tissue to 
‘subcutaneous tissue through a series of dogs. 
“The tumors after reaching the maximum of growth may disappear 
Spontaneously with or without ulceration. : 
“The tumors may continue to increase, and may cause death by 
-secondary deposits forming in the viscera. 
“If the tumor should disappear the animal is then immune to sub- 
sequent inoculation.” 
Beebe and Ewing have studied these nodular tumors. They have 
been able to transplant them. From 122 plants by various methods they 
have produced tumors in 35 cases and there were 12 spontaneous 
recoveries. The course of the successful implantations is usually 
‘quite uniform. When inserted beneath the skin a period of two to 
three weeks elapsed before enlargement was noticed. Thereafter the 
nodules grew steadily in size for four or five months producing a well- 
‘circumscribed tumor the size of a hen’s egg or larger. These authors 
did not determine the histological classification of the tumor. 
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