98 THE DUCTLESS GLANDS. 
What changes take place in the thyroid in goitre ? 
There may be an enlargement of the gland by a simple hyperzemia, 
but in true goitre the increase in size is caused by the formation of new, 
and the enlargement of old, gland alveoli. There is also more or less 
colloid degeneration. Accumulation of fluid, colloid, blood, etc., in the 
gland alveoli may cause the formation of cysts. There may be 
hemorrhages, pigmentation, calcification, purulent or indurative inflam- 
mation. Carcinomata or sarcomata may be associated with the goitre. 
What is the appearance of the thyroid in myxedema ? 
The gland is atrophied. The parenchyma is replaced to a greater 
or less extent with fibrillar connective tissue and newly-formed reticular 
tissue. 
What tumors have been found in the thyroid ? 
Sarcomata, usually primary growths, melano-sarcomata and car- 
cinomata. : 
THYMUS GLAND. 
What pathological changes have been observed in the thymus ? 
Small hemorrhages, suppurative inflammations, syphilitic and tuber- 
cular inflammation and sarcomata. 
SUPRA-RENAL CAPSULES. 
What form of inflammation is most frequent in the supra-renal 
capsules ? 
Tubercular inflammation. The organs are increased in size, and 
their normal structure is replaced by tubercle tissue, connective tissue 
and cheesy matter. These are the changes found in ‘* Addison’s 
disease.” Suppurative inflammation has heen seen in a few cases, 
What forms of degeneration have been found ? 
Fatty degeneration of the cortical part is the rule in adults, but in 
children under five years of age it is a pathological condition. 
Amyloid degeneration may involve a part or the whole of the organ. 
What tumors have been found in the supra-renal capsules ? 
Carcinomata, sarcomata, neuromata and gliomata have been 
observed. 
