Pathogenesis 419 



Pathogenesis. — ^The organism seems to be scarcely pathogenic 

 for animals. Kirchner was able to kill a guinea-pig by intrapleural 

 injection, and Neisser, who performed numerous experiments upon 

 mice, guinea-pigs, and rabbits, only once succeeded in producing a 

 fatal infection, by the intraperitoneal injection of 0.4 cc. of bouillon 

 culture. In this animal the cocci were found in all the internal 

 organs. As has already been said, the organism is found associated 

 with superficial inflammatory conditions of the mucous membrane. 

 It is probably most common in influenza. It has also been 

 found in conjunctivitis, in bronchitis, in whooping-cough, and in 

 pneumonia. 



