536 



Infective Jaundice 



about a week, the micro-organisms live in the blood. In whatever 

 organ they may be found they are either in the capillaries, the lymph 

 spaces or the intercellular spaces. In unusual instances they may 

 enter into epithelial cells, especially those of the liver. Presumably 

 dead organisms are sometimes seen in phagocytic cells of the blood. 

 In animals, as a rule, the greatest number of micro-organisms is to 

 be found in the liver, the next greatest in the adrenals and kidneys. 

 In the liver large numbers surround the individuar liver cells like a 

 garland; in the kidneys they occur inside the interstitial tissues and 

 also in the walls and lamina of the uriniferous tubules, then entering 

 the urine in large numbers. There are few in the spleen, bone mar- 



Fig. 207.— Weil's disease. Spirochaetse in the liver of a patient autopsied on the 

 sixth day. (Inada, Ido, Hoki, Kaneko and Ito.) 



row or lymph nodes. Diffuse hemorrhages in any organ always con- 

 tain them. In the icteric or second stage they disappear from the 

 blood and are destroyed in most of the organs, though they can be 

 constantly found in the kidneys and cardiac muscle. In the third ov 

 convalescent stage they are abundantly excreted in the urine and die 

 out in all the organs. The varying occurrence and distribution 

 depend upon the development and destructive effects of immune 

 bodies. In man the post-mortem examination of organs showed the 

 greatest number of spirochsetae in the kidneys. They escaped in the 

 lumen where they were caught in tube casts in those dying before 

 the 9th day and were free in the tubules in those succumbing about 



