546 



Sleeping Sickness 



micro-organisms and African lethargy, and much interest was being 

 taken in a coccus — the hypnococcus — that was being studied by 

 Castellani in Uganda. As Castellani* was prosecuting the investi- 

 gation of this organism, he chanced to exariiiiie the cerebro-spinal 

 fluid of several negroes in Uganda who were suffering from sleeping 

 sickness, and in it found trypanosomes. Even then, though Cas- 

 tellani realized that these organisms were connected with sleeping 

 sickness, he did not identify them in his mind with the Trypano- 



Fig. 211. — Various species of trjrpanosomes: i, Trypanosoma lewisi of the rat; 

 2, Trypanosoma lewisi, multiplication rosette; 3, Trypanosoma lewisi; small form 

 resulting from the disintegration of a rosette; 4, Trypanosoma brucei of nagana; s, 

 Trypanosoma equinum of caderas; 6, Trypanosoma gambiense of sleeping sickness; 

 7, Trypanosoma gambiense, undergoing division; 8, Trypanosoma], theileri, a harm- 

 less trypanosome of cattle; 9, Trypanosoma transvaliense, a variation of T. theileri; 

 10, Trypanosoma anum, a bird trypanosome; 11, Trypanosoma damonice of a 

 tortoise; 12, Trypanosoma solea of the flat fish; 13, Trypanosoma^ grarmlosum of 

 the eel; 14, Trypanosoma raja of the skate; 15, Trypanosoma rotatorium of frogs; 

 1 6, Cryptobia borreli of the red-eye (a fish) . (From Laveran and Mesnil.) 



* The Lancet, London; June 20, 1903. 



