S64 



Kala-Azar 



Leishman's, or Jenner's stains) and examined under a high magnifi- 

 cation, it is found that the protoplasm takes a pinkish color and 

 contains two well-defined bright red bodies. The larger of these 

 is ovoid and lies excentrically, its long diameter corresponding to 





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J.K^'*>i. 



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-^^ 'mi 



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^y 4, ^n Jr^-^' 



Fig. 220. — Evolution of the parasite of kata-azar: i to $. Parasites of kala- 

 azar. i. Isolated parasites of different forms in the spleen and liver; 2, division 

 forms from liver and bone-marrow; 3, mononuclear spleen cells containing the 

 parasites; 4, group of parasites; s, phagocytosis of a parasite by a polynuclear 

 leukocyte. 6 to 15. Parasites from cultures. 6, First changes in the parasites. 

 The protoplasm has increased in bulk and the nucleus has become larger; 7, 

 further increase in size; vacuolization of the protoplasm; 8, division of the en- 

 larged parasite; 9, evolution of the flagella; 10, smaU pyriform parasite showing 

 flagellum; 11, further development and division of the parasite; i2,flagellated 

 trypanosoma-like form; 13, 14, flagellated forms dividing by a splitting off of a 

 portion of the protoplasm; 15, narrow flagellated parasites which have arisen by 

 the type of division shown in 13 and 14 (From Mense's "Handbuch," after 

 Leishman). 



the long diameter of the organism. This is regarded as the nucleus. 

 The second body is smaller, of bacillary shape, usually lies with its 

 long diameter transverse to the nucleus, stains more intensely than 

 the nucleus, and is looked upon as the blepharoplast. In addition 

 to these bodies the protoplasm may contain one or two vacuoles. 



