626 Spirillum of Gamaleia 



tization and cholera infection, tlie temperature of the animal rises for a short time, 

 then abruptly falls to 33°C. or less. Death follows in from twenty to twenty-four 

 hours. A distinct inflammation of the intestine, with exudate and numerous 

 spirilla, may be found. The spirilla can also be found in the heart's blood and in 





Fig. 232. — Spirillum metchnikovi, from an agar-agar culture. Xiooo (Itzerott 



and Niemann). 



the organs of such guinea-pigs. When the bacilli are introduced by subcutane- 

 ous inoculation, the autopsy shows a bloody edema and a superficial necrosis of 

 the tissues. 



The organisms can be found in the blood and all the organs of pigeons and 

 young chickens, in such large numbers that Pfeiffer has called the disease Vibrio- 



Fig. 253. — Spirillum metchnikovi; puncture culture in gelatin forty-eight hours 

 old (Frankel and Pfeiffer). 



nensepticamia. In the intestines very few alterations are noticeable, and very 

 few spirilla can be found. 



Immvuiity. — Gamal6ia has shown that pigeons and guinea-pigs can be made 

 immune by inoculating them with cultures sterilized for a time at a temperature 

 of ioo°C. Mice and rabbits are immune, except to very large doses. 



