792 Mycetoma, or Madura-foot 



as a tuft of delicate whitish filaments, springing from the black grain, 

 and in a few days covering the entire surface of the medium with a 

 whitish or pale brown felt-work. Upon potato this felt-work sup- 

 ports drops of brownish fluid.- The long branched hyphee thus 

 formed were from 3 to 8 ^i in diameter, with transverse septa in the 

 younger ones. The older h3^hae were swollen at the ends. No buds 

 were observed. No fruit organs were detected. In fluid media the 

 filaments radiated from the central grain with the formation of a 

 kind of puff-ball. Eventually the whole medium becomes filled with 

 mycelia and a definite surface growth forms. 



The general characterfstics of the fungus are well shown in the 

 accompanying illustrations from Wright's paper. 



Pathogenesis. — No results followed the introduction of the gran- 

 ules from the original lesions, or of the cultures made from them, 

 into experiment animals. 



Lesions. — These are not essentially different from those of the 

 other form of the disease and consist of granulation tissue, more or 

 less atypical in structure, with numerous small foci of suppuration. 

 The granules lie at the center and are surrounded by giant and epi- 

 thelioid cells with many lymphocytes and plasma cells. The occur- 

 rence of suppuration causes this structure to be disrupted. 



