264 



INFECTIVE DISEASES. 



of scarlet fever in man, twice in association with certain other 

 micro-organisms, and three times alone. The micro-organisms were 

 isolated by inoculating tubes of nutrient gelatine, solidified obliquely, 

 by streaking the surface with blood taken from the finger, the arm, 

 or the heart after death. Those cases from which the organism was 

 obtained were all oases with ulcerated throat, and the culture 

 experiments, from the living patient, were made on or about the day 

 at which the temperature was at its maximum. 



Name of Patient. 



L F 



aged 5 



K -F — 



aged 2 



H L , 



aged 8 

 (a woman), 



aged 40 

 (a girl), 



aged 19 

 B M , 



aged 15 

 E W , 



aged 22 

 R H , 



F G- — , 



aged 2^ 



E— F , 



aged 3 



E B , 



aged 20 months 



Condition of 

 Tonsils. 



Severely- 

 ulcerated 



Much 

 ulcerated 



Ulcerated 



Much 

 ulcerated 



Ulcerated 



Much 

 ulcerated 

 Ulcerated 



Advanced 

 ulceration 



Source 



of 

 Blood. 



Micio-Organisms 

 Isolated. 



Finger 



Arm 



Finger 



Heart 



Streptococcus 



(Staphylococcus 

 pyogenes aureus 

 Liquefying micro- 

 coccus 

 Streptococcus 

 f Staphylococcus 

 \ Streptococcus 

 None 



Streptococcus 

 None 



Streptococcus 

 None 



Death or 

 Recovery. 



Ultimately 

 recovered. 



. Died of 

 pyaemia. 



>- Recovered. 

 [Not stated.] 



Recovered. 

 [Not stated.] 



?» 

 Died. 



Klein regards this streptococcus as the actual cause of scarlet 

 fever in man. 



The author, Raskin, Holmes, and others who have investigated this 

 subject agree with the conclusions of Frankel and Freudenberg. The 

 author is convinced that the streptococci in suppuration, puerperal 

 septicaemia, pysemia, and septicaemia, and in certain cases of measles, 

 scarlatina, and diphtheria, are identical; and from overwhelming 

 evidence we are justified in concluding that — (1) The nature of 

 the contagium of scarlet fever is unknown. (2) The streptococcus 

 regarded by Klein as the contagium is the Streptococcus pyogenes. 



