452 INFEC?riVE DISEASES. 



nostrils and swelling of the glands, and notliing more will be visib] 

 until a post mortem examination has been made. 



Glanders in man is found amongst those whose duties brin 

 them into contact with diseased horses, such as stable-men, cavalr 

 soldiers, and veterinary surgeons ; and it is generally the resu] 

 of accidental inoculation of a wound. An abscess develops, foUowe 

 by metastatic purulent infiltration of the lungs, liver, spleen, an 

 bones. There may be oedematous swelling of the face and ulcer 

 in the nostrils. The joints may become swollen and painful. 



The nodules consist of fibrous tissue and cells, with a tendency t' 

 suppuration. In the lungs the disease spreads by the lymphatics 





.^-^iU^i-"^^^'"'^"'^''^ 



Fis. 184. — Bacilli of Glanders ; section of a glanders nodule, x 700 (Flugse). 



The infiltrated patches are necrosed in the centre, which is sur- 

 rounded by leucocytes and fibrous tissue. 



The bacilh were discovered by Loffler and Schutz in 1882. They 

 are found in the discharge from the nostrils, in the pus, and in the 

 nodules of animals artificially infected. 



Bacillus mallei — Rods, with rounded ends, shorter and 

 thicker than the tubercle bacillus, occurring singly, or in pairs, 

 and sometimes in filaments. The protoplasm in the rod is broken 

 up in stained preparations, as in the tubercle bacillus. They stain 

 with the watery anihne dyes, and intensely so with alkaline methylene 

 blue or Neelsen's solution ; they are non-motile and aerobic ; spore 

 formation has been described. They can be cultivated on the usual 

 media, especially on glycerine- agar and on potato ; but they will not 

 grow in infusions of hay, straw, or stable manure. On the surface 

 of glycerine-agar a colourless, transparent growth occurs on either 



