CATTLE PLAGUE. 295 



days afterwards, a small, slightly elevated, hard pimple was felt 

 and seen on the site of the puncture. This gradually advanced 

 tUl the ninth day of the puncture, the fourth from papulation, 

 when the enlargement became distinctly vesicular. At that time 

 there were but slight constitutional symptoms. On the next day, 

 the tenth from the receipt of the puncture, the fifth from papulation, 

 and the second from vesiculation, Mr. Hancock consulted Mr. Rayner, 

 of Uxbridge, who, on seeing the hand, inquired if the patient had 

 been handling the udder of a cow, as he thought he could recognise 

 a cow-pox vesicle of the ninth day. The vesicle was distended 

 ■with thin lymph, its margin elevated and slightly brown, its centre 

 depressed and brownish, and the whole surrounded with a large 

 bright red areola. There was then considerable tumefaction extend- 

 ing from the knuckles to above the wrist. The absorbent vessels 

 were considerably inflamed, and, like the axillary glands, were tender 

 and painful ; the pulse, naturally -slow, was accelerated ; there was 

 much pain in the back and limbs, severe distracting headache, etc. ; 

 all of which symptoms continued to inci-ease dux'ing the two following 

 days. At the end of that time the diffused areola had extended as 

 far as the elbow. Fifteen days after the puncture, and ten days after 

 papulation, the local inflammation and constitutional symptoms had 

 partially subsided. The vesicle contained a rather turbid brownish 

 fluid, and there were present all the indications of a declining vaccine 

 vesicle. 



Murchison also saw and described the case, and gave practically 

 the same account of it. He pointed out that the appearances and 

 the entire history were very different from the results of a poisoned 

 wound, but coincided with the appearances seen after vaccination. 



In 1832 Macpherson, in Bengal, inoculated eleven native children 

 with cattle-plague crusts. There was no result in six, others 

 suffered from local inflammation, and in one a vesicle formed. 

 With lymph from this vesicle other children were inoculated. The 

 results in all were similar in appearance to those of vaccination. 

 Two children were subsequently inoculated with human variola, and 

 were said to be protected. 



In 1834 Macpherspn's example was followed by Mr. Furnell 

 in Assam. Furnell inoculated four children with cattle-plague 

 crusts without result, but his assistant succeeded with crusts taken 

 from the back and abdomen of the diseased cattle, and carried on 

 the lymph from child to child. In one case there was a general 

 eruption. Furnell inoculated his own child from one of the native 

 children : a copious eruption followed, and the child died. Furnell 



