306 INFECTIVE DISEASES, 



and an eruption upon the skin. The horse, too, from which the 

 infectious matter was procured for inoculation, had a considerable 

 indisposition, previous to the disease at his heels, which was attended, 

 as in the others, with an eruption over the greatest part of his 

 body ; but those that did not communicate the disease at all, had 

 a local affection only. Prom this perhaps may be explained the 

 want of success attending the experiments of the gentlemen I have 

 mentioned." 



Experiments with horse-pox were also made about this time on 

 the Continent. Sacco made some observations upon this disease at 

 Milan. Several horses were suffering from what was called giardoni, 

 and Sacco's servant was attacked on both arms, from dressing one 

 of his horses troubled with this disease. Several children and cows 

 were inoculated from the horses, but vidthout success. In another 

 instance, a coachman went to the hospital vsdth the eruption on his 

 hands, and the disease was successfully communicated to three out 

 of nine children. 



In 1803 Dr. Marcet described some experiments which had been 

 made at Salonica by M. La Font. The disease was known to the 

 farriers in Macedonia as javwrt. In one ease, a horse was attacked 

 with feverish symptoms that ceased as soon as the eruption appeared. 

 The fore legs were much swelled and several ulcers formed. M. La 

 Font took some of the discharge from an ulcer and inoculated a cow 

 and three children, and succeeded in transmitting the disease to two 

 of the latter. 



Vaccinogenic grease was observed in Paris in 1812, and Baron 

 cites the case of a coachman who, after dressing a horse with the 

 " grease," had a crop of pustules on his hands, from which the disease 

 was experimentally transmitted by inoculation to two children. A 

 series of inoculations was started from an infant who was infected 

 from one of the scabs taken from the pustules on the hand of the 

 coachman. 



In 1813 Mr. Melon, a surgeon at Lichfield, met with vaccinogenic 

 grease in the horse, and some of the virus was sent to Jenner, who 

 carried on a series of arm to arm equinations for some months. And 

 again in 1817, vaccinogenic grease broke out in a farm at Wansell. 

 The farm-servants and the cows were infected, and Jenner employed 

 this equine matter for a series of inoculations for eight months. 



In 1817 Baron described a case of a young man who had not less 

 than fifty pustules on his hands and wrists from dressing a horse vidth 

 this disease, and in the following year Baron obtained some fresh 

 equine virus from the hands of a boy who had been infected directly 



