308 INFECTIVE DISEASES. 



jambes. Amyot had a wound on the dorsal aspect of the first inter- 

 phalangeal joint of the Uttle finger of his right hand ; in spite of 

 this, he continued to dress the horse entrusted to his care. The 

 wound, on his finger became accidentally inoculated with the virus, 

 which flowed in great abundance from the horse's leg. 



The wound was made on August 3rd, and the next day it was 

 swollen, and rather painful. On the 5th, Amyot suffered from malaise 

 and great weakness; on the 6th, 7th, and 8th, vesicles appeared 

 successively on the fingers of his left hand, and on his forehead 

 between the two eyebrows. On the 9th, these vesicles were fully 

 developed ; those of the fingers consisted of very large epidermic 

 bullse on a bluish-red base. On opening them, a perfectly limpid 

 fluid escaped in such abundance that small test-tubes might have 

 been filled with it. The vesicle on the forehead was surrounded by 

 a bluish- red areola, within which, the epidermis, of a leaden-grey 

 hue, was raised, and had a slight central depression. The liquid 

 which flowed from it when it was opened, and which continued to 

 ooze, was also very abundant and of a deep citrine colour. 



The vesicles which had developed on the dorsal side of Amyot's 

 fingers were extremely painful. The incessant shooting pains, of 

 which they were the seat, prevented him from getting any rest for 

 three days. On the 10th, inflammation of the lymphatics followed ; 

 both arms were swollen and very painful, with red lines indicating 

 the course of the lymphatic vessels. The glands of the axillse were 

 also enlarged. 



The lymphatic glands behind the jaws were also swollen and pain- 

 ful. Amyot's chief sufferings were occasioned by the intense local 

 pain caused by the vesicles on the fingers, and by the inflammation 

 of the lymphatic vessels and glands, which continued in this state up 

 to the 18th of August. It was only at the end of the month that the 

 vesicles were completely cicatrised. 



Bouley felt very great anxiety in the presence of the grave 

 symptoms which accompanied the eruption. The eruption on the 

 forehead was especially a cause of great uneasiness, because glanders 

 manifests itself in a similar way. 



With virus from Amyot's vesicles the disease was transmitted to 

 cows and to children. 



Further, this outbreak enabled exhaustive experiments to be 

 made, by which it was definitely established that horse-pox is never 

 infectious, but, like cow-pox, is transmitted solely by contact. 



In 1880, M. Baillet, Director of the National Yeterinary School 

 of Toulouse, was informed that a contagious malady had developed 



