320 INFECTIVE DISEASES. 



" A young woman had cow-pox to a gftat extent, several sores which 

 maturated having appeared on the hands and wrists. 



" A young woman had several large suppurations from cow-pox on the 

 hands." 



Pearson in his investigations encountered, and was informed of, 

 similar experiences. 



" Thomas Edinburgh was so lame from the eruption of cow-pox on 

 the palm of the hand as to necessitate his being for some time in hospital. 

 For three days he had suffered from pain in the armpits, which were 

 swollen and sore to the touch. He described the disease as uncommonly 

 painful, and of long continuance. 



" A servant at a farm informed Pearson that in Wiltshire and 

 Gloucestershire the milkers were sometimes so ill as to lie in bed for 

 several days. 



" Mr. Francis said that cow-pox was very apt to produce painful sores 

 on the hands of milkers. 



" A servant of Mr. Francis said that cow-pox affected the hands and 

 arms of the milkers with painful sores as large as a sixpence. 



" Mr. DoUing describes the disease as ' a swelling under the arm, chilly 

 fits, etc., not different from the breeding of the small-pox. After the 

 usual time of sickening, namely, two or three days, there is a large ulcer,, 

 not unlike a carbuncle, which discharges matter.' 



" Dr. Pulteney described the disease as causing 'a soreness and swell- 

 ing of the axillary glands, as under inoculation for the small-pox, then 

 chilliness and rigors and fevers, as in the small-pox. Two or three days 

 afterwards abscesses, not unlike carbuncles, appear generally on the hands 

 and arms, which ulcerate and discharge much matter.' 



" Mr. Bird wrote a short account : ' It appears with red spots on the 

 hands, which enlarge, become roundish, and suppurate, tumours take 

 place in the armpit, the pulse grows quick, the head aches, pains are felt 

 in the back and limbs, with sometimes vomiting and delirium.' 



" Annie Francis had pustules on her hands from milking cows. These 

 pustules soon became scabs, which, falling off, discovered ulcerating and 

 very painful sores, which were long in healing. Some milk from one of 

 the diseased cows, having spurted on the cheek of her sister and on the 

 breast of her mistress, produced on these parts of both persons pustules 

 and sores similar to her own on her hands." 



In more recent times these descriptions have been confirmed. 



In 1836 cow-pox was discovered at Passy, near Paris. A black 

 cow, in very poor condition, had cow-pox six weeks after calving. 

 Bousquet had no opportunity of seeing the eruption in the early 

 stage, but on examination he found reddish-brown crusts on the 

 teats, which later gave place to puckered scars. The milk- woman, 

 Fleury, who had had small-pox, nevertheless contracted the disease 

 from the cow. She had several vesico-pustules on the right hand 



