184 NOTES 



155. (p. 165). Behring, Infektion und Desinfektion, p. 160, and Deutsche mediz. 



Wochenschr. 1893, No. 48. WLADIMIROFF, Ueber die antitoxinerzeugende 

 und immunisierende Wirkung des Tetanusgiftes, Zeitschr. f. Hygiene, xv. 1893.' 



156. (p. 165). If this assumption were correct it would explain the well-known fact 



that only the earliest stages of diphtheria can be successfully treated by the 

 serum method. It would account too for Koch's observation (note 143) that 

 the new tuberculin T. R. must be. used within one or two weeks of inoculation 

 if it is to have a really curative effect. In all these cases the toxines introduced 

 artificially may be imagined to bring about toleration before the body is inundated 

 with poison from the bacterial centres. 



157. (p. 166). ROUX, Sur les serums antitoxiques (Ann. Pasteur 1894), thinks it probable 



that the antitoxines act upon the tissue cells and make them insensitive to the 

 toxines. Behring (Infektion und Desinfektion) is inclined to think the toxines 

 are destroyed by the antitoxines. 



158. (p. 166). BEHRING in the works cited ; also in Die Geschichte der Diphtherie, 



Leipzig 1893, and Gesammelte Abhandlungen zur atiologischen Therapie, 

 Leipzig 1893. Ehrlich, Die staatliche Kontrolle des Diphtherieheilserums, 

 Berl. klin. Wochenschr. 1896. 



159. (p. 166). Of the innumerable works on the value of serum therapeutics that have 



already appeared may be mentioned : Behring, Die Statistik der Heilserum- 

 frage, Marburg 1895 ; Heubner, Klinische Studien iiber die Behandlung der 

 Diphtherie mit dem Behring'schen Heilserum, Leipzig 1895 ; ESCHERICH, 

 Diphtherie, Croup und Serumtherapie, 1895 ; Gottstein and SCHLEICH, 

 Immunitat, Infektionstheorie und Diphtherieserum, Berlin 1894; Ganghofner, 

 Die Serumbehandlung der Diphtherie, Jena 1897. 



160. (p. 166). Pfeiffer, Die Differentialdiagnose der Vibrionen der Cholera asiatica 



mit Hilfe der Immunisierung, Zeitschr. f. Hygiene, xix. 1895; Pfeiffer, 

 Centralbl. f. Bakt., xix. 1896, pp. 191, 385, 593; ibid. xx. 1896, p. 129. 

 Bordet, Sur le mode d'action des serums preVentifs, Annales Pasteur, 1896. 

 Dunbar, Zur Differentialdiagnose der Choleravibrionen, Zeitschr. f. Hygiene, 

 vol. xxi. 



161. (p. 167). PFEIFFER and Proskauer, Beitrage zur Kenntnis der spezifisch wirksamen 



Korper im Blutserum von choleraimmunen Tieren, Centralbl. f. Bakt., xix. 

 1896, p. 197. 



162. (p. 168). Pasteur, Comptes rendus, Oct. 26, 1885, and in many other papers 



on this very remarkable inoculation, which is indeed a kind of serum treatment. 

 For the organs employed (cord and brain) contain not only the postulated 

 antitoxin, but also the poison which is thus introduced into the bitten animals, 

 only by a different vehicle. Pasteur's genius did not need pure cultures of 

 the unknown hydrophobia germ, and this gives us a right to hope that we may 

 succeed with his method in the case of other diseases. 



163. (p. 168). Chamberland, Resultats pratiques des vaccinations contre le charbon 



et le rouget en France, Annales Pasteur, viii. 1894; see also note 17. 



164. (p. 168). Gruber, Miinchener mediz. Wochenschr. 1896, applies the term ' glabri- 



ficines ' to the substances in the blood of immunized animals, which cause the 

 membranes of the bacteria to swell up, and the rods themselves to agglutinate. 

 'Lysines' and 'antilysines' were introduced by Krusse (Flugge, Mikroorg.j 

 3rd ed., vol. i. pp. 409, 414). Of all these substances we know only the names. 



