146 TBTEEIlfABY MATERIA MEDICA. 



pilocarpine, which is soluble in alcohol, ammonia, 

 ether, chloroform, and dilute acids, forming crystal- 

 lizable salts — the nitrate and hydrochlorate being 

 chiefly used. Another alkaloid — jaborine — also oc- 

 curs, but only in small quantity, and physiologically 

 it is antagonistic to pilocarpine. 



Prepaeations. — Extractum Pilocarpi Fluidum, 

 fluid extract of pilocarpus. Dose: H., fl. 3 ij.-viij. ; 

 D., m x.-fl. 3i. 



Pilocarpines Hydrochloras, hydrochlorate of pilo- 

 . carpine ; Pilocarpince Nitras, nitrate of pilocarpine. 

 Dose: H., gr. ij.-v. ; D., gr. iV4-; for subcutaneous 

 injection. 



Physiological Action. — Jaborandi stimulates 

 peripheral nerve endings supplying involuntary mus- 

 cular fibre and glands; is also a paralyzer of the 

 vasomotor system, a diaphoretic, a sialogogue, and 

 depresses the heart by stimulation of the vagus ends. 

 Its myotic and emetic properties are not well marked 

 on the lower animals, excepting the canine species. 

 The same is true of its diaphoretic action, which in 

 the dog is quite prominent, but on the horse and ox 

 is quite uncertain and can only be induced if the ani- 

 mal be heavily clothed and given warm drinks along 

 with full doses of the drug. The nasal, buccal, bron- 

 chial, and lachrymal secretions are very much in- 

 creased, and sometimes a watery diarrhoea accom- 

 panies the administration of the drug, due to its 

 powerful stimulant effect upon the muscular coat of 

 the intestines as well as on the intestinal glandular 

 apparatus. "When first given, the cardiac action is 



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