AimzTMOTICS, ANTIPYRETICS, ANTIPEEIODICS. 161 



ing. This may be avoided by giving the drug in 

 aerated w^ater. It is rapidly absorbed and but slowly 

 eliminated, vv^hich last process is carried on chiefly by 

 the kidneys. It does not lower the body tempera- 

 ture in health, but has great power to do so in ab- 

 normal body temperature, whether given internally, 

 subcutaneously, or intratracheally. Its effects as a 

 febrifuge are due to diminished heat-production. 

 Occasionally it will produce a profuse perspiration, 

 vertigo, collapse, and in the dog at times a rash re- 

 sembling that of measles. Antipyrine may be given 

 in all febrile and inflammatory diseases, influenza, 

 acute muscular and articular rheumatism, and dia- 

 betes insipidus, in doses for the horse of 3 i.-iv. ; for 

 the dog, gr. v.-xx. Externally — it is employed in 

 five- to ten-per-cent. solutions as a hsemostatic ; sub- 

 cutaneous injections of the drug are used to relieve 

 pain and nervous irritability in the treatment of colic 

 (dose about one-third of that per os). 



ACETANILIDUM — ACETANILID. 



(Known also as Phenyl Acetamide, Antifebrin [a 

 trade name].) 



Acetanilid is obtained by the reaction of glacial 

 acetic acid on anilin. It occurs as colorless or whit- 

 ish, shining, odorless crystals, having a slightly 

 burning taste and a neutral reaction. Soluble in 190 

 parts of cold water, in 18 parts of boiling water, and 

 in 3i parts of alcohol ; also soluble in chloroform and 

 ether. Dose: H., 3 i.-ij. ; D., gr. v.-xv. 

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