326 BACTERIA. 



fourth, and then again 12 and lo cords on the fifth, and so on through a 

 third series, the whole treatment lasting 14 or 15 days. 



Cornil and Babes have collected some most interesting statistics, which 

 we may here quote. In the Institut Pasteur in 1886, out of 2,682 cases 

 treated, there was a mortality of 13.4 per 1,000; in 1887, in 1,778 cases, 

 a mortality of II. 2 per l,00o; in 1888 7.7'per. 1,000; and in 1889 5.4 

 per 1,000. In St. Petersburg, in 484 patients treated, the mortality was 

 26.8 per 1,000; in Odessa, in 1,135 treated, 17. i per 1,000; in Moscow, 

 out of 107 treated, 34 per 1,000 ; but out of 500 inoculated with stronger 

 virus, and for a longer period, the mortality was only 13 per 1,000. • At 

 Warsaw, of 297 people treated by the milder method, 80 per 1,000 suc- 

 cumbed ; whilst of 370 inoculated by the intensive method, none succumbed 

 to hydrophobia. At Charkow, of 233 treated, there was a mortality of 

 38 per 1 ,000 ; at Turin, of 502 treated in cases where the dogs were un- 

 doubtedly rabid, there was a mortality of 25 per i ,000 ; at Bucharest, out 

 of 310 patients, a mortality of only 2.9 per 1,000 ; at Naples, of several 

 hundreds treated, the mortality was only 15 per 1,000 ; and at Havannah, 

 where there were 170 patients, only 6 succumbed. 



The factor of time between the bite and the commence- 

 ment of the treatment plays a most important part, and it 

 has been found that there is always the greatest success 

 obtained in the cases of those patients who submit them- 

 selves for treatment within two or three days of being bitten. 

 One of the most convincing proofs of the efficacy of this 

 inoculation that has been given, is that recorded by Babes. 

 Thirteen men and thirty animals, cattle, horses, pigs, and dogs, 

 he states, were attacked by rabid wolves ; of the thirteen men 

 so attacked, twelve came to Bucharest for treatment, and all 

 of them recovered except one whose head was fearfully torn 

 and lacerated by the fangs of a wolf ; the thirteenth man, 

 who would not present himself for treatment, died of 

 hydrophobia. A very significant fact was that every one of 

 the thirty animals succumbed to typical hydrophobia. The 

 patient who died succumbed ten days after the completion 

 of a very intense and prolonged treatment (thirty-two days). 

 The other patients were then subjected to a further treat- 

 ment during six days of mixtures of two cords from the 

 twelve days down to the one day ; and as we have seen they 

 all recovered. 



It is interesting to note in connection with Galtier's 

 early observations, which were at first supposed to be dis- 

 proved by Pasteur, that they were confirmed by Nocard 

 and Roux, and by Vestea and Zagari, who have proved 

 that the injection into the blood of rabic virus does not 

 always produce hydrophobia, and that in certain ruminants, 



