TUMORS. 219 
tried, in particular the solution of methylene blue; treatment recom- 
mended for man by Mosetig-Moorhof and Darier.' 
Arsenical preparations (Fowler solution, arsenious acid) and iodine, 
recommended against sarcomas.and lymphadenomas, have but little efficacy. 
We have often used them without the slightest advantage. Iodide of 
potassium has never produced a satisfactory change in the growth of 
neoplasms; it rather seems to stimulate their growth by the disturbances 
it gives rise to. As local applications, or to be taken internally, a number 
of compound mixtures, “ antineoplastic ” plants have been recommended, 
all without the slightest use. Electricity, which has given some success- 
ful results in the therapeutics of the uterine tumors of women, has not 
been much used in veterinary practice. 
Some microbian inoculations have also been proposed for cancer. 
Among these it has been said that the streptococcus of erysipelas injected 
into sarcomas and carcinomas could arrest the process and bring on re- 
covery, the tumors becoming affected with fatty degeneration and disap- 
pearing. We know also that this result has taken place spontaneously 
without those injections. Bacteriotherapeutics seems to have succeeded 
only in cases of such nature. 
At the present time the only rational therapeutics of malignant tumors 
is extivfation. ‘To obtain allthat it can give, it must be radical and early. 
To make it radical, one must bear in mind that almost all these growths 
are surrounded by a zone infiltrated with neoplastic elements, though no 
alteration manifest to the naked eye can be observed in them. When 
secondary tumors are already developed round a diffused primitive 
neoplasm, the latent zone of infection may at times be very wide and 
then the ablation must be quite extensive. Ifthe skin is more particularly 
the seat of this neoplastic infiltration this extends deeply into the con- 
nective lamellz on the surface of the aponeurosis and into the thickness 
of all the tissues of that region. Independently of this zone of infection 
which surrounds the tumor, there is another formed by the blood vessels 
and the surrounding lymphatic glands; the latter is almost always rapidly 
overrun with the neoplasms of epithelial origin ; often it is already infected 
when exploration fails to reveal any alteration; most often, however, the 
lymphatic vessels show small nodosities here and there along their length, 
and their collecting glands are hypertrophied and indurated. In such 
cases the removal of the growth must necessarily be completed by that of 
the infected lymphatic structure. Numerous are the mammary neoplasms 
of sluts that demand such extensive removals. The trouble must be fol- 
lowed up in the groin to its roots. Some of the diseased glands cannot 
be reached; operation is then powerless to bring about recovery. It is 
1 Mosetig-Moorhog, Darier : Semaine Medicale, 1894, pp, 228 and 238, 
