MORBID ANATOMY 223 



color and less dense in texture than the central mass, evidentlj' 

 ^^..^ an extension of the growth. 



21 \ In the specimens examined 



the parts where the lesions 

 abounded were not characterized 

 bj' a rich vascular supply. The 

 few vessels that were encoun- 

 tered were not of a normal char- 

 acter ; their walls were thick- 

 ened, and the endothelium, in- 

 FiG. 50. Fro,/i the same Up, stead of presenting the usual 

 but shoxi's a larger infeeted area, flattened appearance, was irreg- 

 {Fish.) ularly cylindrical. Although the 



condition was not observed, it is not impossible that the 

 hyphse of the fungus may develop to such an extent as to 

 compress or actually penetrate the walls of the vessels, caus- 

 ing inflammatory changes sufficient to permit, in the course of 

 time, a disorganization or absorption of a portion of the ves- 

 sel itself, and that ultimately it may become incorporated in 

 the nodule. 



The nodules are generally irregularh? cone shaped and are 

 of variable size. In section they reveal a very dense structure, 

 the framework of which forms a close reticulum. 



Within the meshes are what appear to be 

 leucocytes in various stages of disintegration, 

 and free nuclei. Among these, at places, 

 there can be seen small bodies of nearly the 



same size as the nuclei and taking the stains Fig. 51. An 



in the same wav, but differing in form. At isolated nodule 

 ^ . . i- , , , , shoivtiig the ehar- 



one portion of its circumference the substance , . *. , 



i^ ■ aeteristic rough- 



of the body is seen to draw itself toward a ^^^^^ coral-like 



point and in favorable preparations that point appearance of the 

 has been followed some little distance as a mass. (Fish.) 

 delicate filament. In most cases the filament remains un- 

 stained, or, as observed in a Gram-eosin preparation, the club 

 end may stain blue and the filament red. Exceptionally one 

 may find a clear area or vacuole in one of the clubs. From 

 the fact that the filament is not usually traceable to its central 



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