304 THE PATHOGENIC RHIZOPODA 



suborder microsporidia, while Williams later gave the name Neuro- 

 ryctes hydrophobicB to the Negri body. 



The life history of Neurorydes hydrophobice , despite the admirable 

 researches of Williams and Lowden, cannot yet be regarded as estab- 

 lished, nor do I think the stages observed by Negri, Williams, and 

 others justify us in assigning the organism to the sporozoa. The 

 variable form, the uninucleate condition leading to the condition of 

 distributed chromatin, and the budding phenomena are not charac- 

 teristic of sporozoa, but are common to parasitic rhizopods, and the 

 distributed chromatin is, in all probability, the idiochromidia, which, 

 we have seen, is a characteristic phenomenon of all rhizopods. 



Fig. 119 



"Negri bodies." or Neuroryctes hydrophobiaj, in different stages of chromatin distribution. 



(After Negri.) 



The organism is most abundant in the region of Ammon's horn, 

 less abundant in the nerve cells of the cerebral cortex, cerebellum, 

 medulla, and cord. In many cases, especially in street rabies, the 

 organisms are large and ameboid in form, measuring up to IS /< (Wil- 

 liams) (to 2.3 /-(, Negri), while minute forms, one-half a micron and less 

 in diameter, are characteristic of the organism after the virus has been 



