222 PRINCIPLES OF ANIMAL NUTRITION. 
Muscular Glycogen.—Especial interest attaches in this connec- 
tion to the behavior of the glycogen of the muscles. Nasse * 
appears to have been the first to show that the muscular glycogen 
is consumed during contraction. This result has been abundantly 
confirmed by other investigators, notably by Weiss,f while, as just 
stated, Kiilz has shown that the same thing is true of the glycogen 
of the liver. 
It has also been shown that glycogen accumulates in muscles 
whose activity has been suspended by section of their nerves or other- 
wise. An early statement to this effect, unaccompanied by experi- 
mental proof, is by MacDonnel.{ Chandelon § investigated the 
influence upon the glycogen content of the hind leg of a rabbit of, 
first, ligature of the arteries, and second, section of the motor nerves. 
The first treatment caused a large loss and the second a large gain 
of glycogen. Morat & Dufourt || confirmed these results and also 
found that the formation of muscular glycogen was more rapid in a 
fatigued quiescent muscle than in a normal one, while Aldehoff 4 
has shown that in a fasting animal glycogen persists longer in the 
muscles than in the liver and reappears first in the former when food 
is given. _ 
In view of these facts it can hardly be doubted that the muscu- 
lar glycogen is in some way a source of energy to the muscles, being 
destroyed during contraction and stored up again during rest. 
Chauveaw’s Interpretation.—By a comparison of their results for 
dextrose just cited on p. 221 with those for the gaseous exchange 
of the muscle as given on p. 188, Chauveau & Kaufmann show that 
during rest there was a storage of dextrose and of oxygen in the 
muscle. During work, on the contrary, more carbon dioxide was 
produced by the muscle than corresponded to the amount of dex- 
trose which was abstracted from the blood, and this carbon dioxide 
contained more oxygen than was supplied to the muscle by the 
* Arch. ges. Physiol., 2, 97; 14, 482. 
{ Sitzungsber. Wiener Akad der Wiss., Math-Nat. Klasse, 64, II, 284. 
t Proc. Roy. Irish Acad., Ser. I, 7, 271. 
4 Arch. ges. Physiol , 18, 626. 
|| Archives de Physiol , 1892, 327 and 457. 
| Zeit. f. Biol., 25, 137. 
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